2025 College Football Week 4 Preview: Key Matchups and Quarterback Showdowns

As the 2025 college football season approaches its first act’s conclusion, Week 4 promises to deliver thrilling matchups and pivotal moments. With conference play on the horizon, teams are eager to solidify their playoff aspirations. This weekend features a mix of high-stakes games, struggling quarterbacks, and potential upsets that could shape the landscape of college football.

Scuffling Quarterbacks: A Make-or-Break Weekend

Florida Gators vs. No. 4 Miami Hurricanes

The Gators, led by quarterback DJ Lagway, face a crucial test against Miami. After a disappointing performance against LSU, where Lagway threw five interceptions, Florida’s offense must find its rhythm. The Gators’ defense has been solid, allowing only 38 points in three games, but they need Lagway to step up against a Miami defense that ranks 83rd in yards allowed per dropback.

Current Line: Miami -7.5
SP+ Projection: Miami by 10.6

Syracuse Orange at Clemson Tigers

Clemson’s Cade Klubnik is in a similar predicament, struggling to meet expectations. With the Tigers ranked 96th in points per drive, they need a breakout performance against Syracuse, who has historically overachieved against them. The return of veteran receiver Antonio Williams could provide a much-needed boost.

Current Line: Clemson -16.5
SP+ Projection: Clemson by 9.2

Southeastern Louisiana Lions at No. 3 LSU Tigers

Garrett Nussmeier has shown flashes of potential but needs to improve his deep passing game. LSU’s offense ranks just 112th in points per drive, and this matchup against Southeastern Louisiana presents an opportunity to build momentum.

SP+ Projection: LSU by 33.0

Sam Houston Bearkats at No. 8 Texas Longhorns

Arch Manning’s struggles continue as he ranks near the bottom in completion percentage and time to throw. Texas needs a dominant performance against a weak Sam Houston defense to regain confidence.

Current Line: Texas -39.5
SP+ Projection: Texas by 40.0

Key Matchups to Watch

No. 9 Illinois at No. 19 Indiana

This matchup marks the first meeting between ranked teams since 1950. Both teams have shown promise, with Illinois and Indiana boasting impressive records. Expect a tightly contested game as both teams aim to maintain their momentum.

Current Line: Indiana -6.5
SP+ Projection: Indiana by 3.9

No. 17 Texas Tech at No. 16 Utah

Texas Tech has been explosive offensively, while Utah’s defense has been solid. This game will be a test of strength as both teams look to establish themselves in the Big 12.

Current Line: Utah -3.5
SP+ Projection: Utah by 1.9

No. 22 Auburn at No. 11 Oklahoma

Oklahoma’s offense has been inconsistent, but they remain undefeated. Auburn’s run game will be crucial as they look to challenge the Sooners’ defense.

Current Line: Oklahoma -6.5
SP+ Projection: Oklahoma by 7.4

South Carolina at No. 23 Missouri

Missouri has exceeded expectations this season, while South Carolina’s offense has struggled. This game could be pivotal for both teams as they aim for bowl eligibility.

Current Line: Missouri -10.5
SP+ Projection: Missouri by 13.7

Group of 5 Showdowns

Arkansas at Memphis

Memphis has been impressive early in the season and faces a tough challenge against an explosive Arkansas offense. This game could have significant implications for the Group of 5’s playoff hopes.

Current Line: Arkansas -7.5
SP+ Projection: Memphis by 0.5

Tulane at No. 13 Ole Miss

Tulane’s inconsistent performances will be tested against Ole Miss, who has shown offensive firepower. This matchup could be a defining moment for both teams.

Current Line: Ole Miss -13.5
SP+ Projection: Ole Miss by 17.5

UNLV at Miami (Ohio)

UNLV has begun to find its footing, but Miami’s explosive offense could pose a challenge. This game is crucial for both teams’ aspirations.

Current Line: UNLV -2.5
SP+ Projection: UNLV by 8.4

Conclusion

Week 4 of the 2025 college football season is set to be a thrilling showcase of talent, strategy, and potential upsets. With several quarterbacks under pressure to perform and key matchups that could alter playoff trajectories, fans are in for an exciting weekend. As teams prepare to enter conference play, the stakes have never been higher.

In summary, this weekend’s games will not only test individual players but also shape the narrative of the season as teams vie for playoff positions. Keep an eye on the quarterbacks, as their performances could be the difference between victory and defeat.